Insulin Receptor alpha Antibody

ELISA (order BSA-free format for coating)

Optimal dilution of the antibody should be determined by the researcher.

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.

This Insulin Receptor alpha antibody is available for research use only.

Protein G affinity chromatography

P06213