Diaclone

Human CD138 ELISA Set

Product Code:
 
851.620.015
Product Group:
 
ELISA Kits
Supplier:
 
Diaclone
Host Type:
 
Human
Regulatory Status:
 
RUO
 

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851.620.01515 x 96£494.00
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Further Information

Antigen Synonyms:
Syndecan-1
Assay Range:
8-256 ng/ml
Cross reaction:
No cross reactivity with other human soluble molecules
Description:
Diaclone ELISA Sets include capture and biotinylated detection antibody one standard per plate Streptavidin-HRP TMB and detailed procedure including buffer composition.
Detection Target:
CD138 / Syndecan-1
Incubation:
From sample to end 1h45
Reactivity:
Human
Research Area:
Cell Adhesion
Sample Size:
100 µl
Sample Types:
Serum Plasma Cell culture supernatant
Sensitivity:
4.94 ng/ml
Specificity:
Recognizes natural human soluble syndecan-1

References

  1. Chen L. and R. D. Sanderson PLoS One2009; 4(3): e4947. Heparanase regulates levels of syndecan-1 in the nucleus.. https://www.ncbi.nlm.nih.gov/pubmed/19305494
  2. Kelly T. et al. Cancer Res. 2003; 63(24): 8749 - 8756. High heparanase activity in multiple myeloma is associated with elevated microvessel density. https://www.ncbi.nlm.nih.gov/pubmed/14695190
  3. Kelly T. et al. J Bone Miner Res.2010?; 25(6): 1295-304. Tumor-derived syndecan-1 mediates distal cross-talk with bone that enhances osteoclastogenesis.. https://www.ncbi.nlm.nih.gov/pubmed/20200931
  4. Khotskaya Y. B. et al. J. Biol. Chem.2009; 284(38): 26085-26095.. Syndecan-1 Is Required for Robust Growth Vascularization and Metastasis of Myeloma Tumors in Vivo.. https://www.ncbi.nlm.nih.gov/pubmed/19596856
  5. Purushothaman A. et al. J. Biol. Chem.2008; M806266200.. Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.. https://www.ncbi.nlm.nih.gov/pubmed/18812315
  6. Seidel C. et al. Blood 2000; 96(9): 3139 - 3146. High levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activity. https://www.ncbi.nlm.nih.gov/pubmed/11049995
  7. Yang Y. et al. J Biol Chem.2007;282: 13326 - 13333 . Heparanase enhances syndecan-1 shedding: A novel mechanism for stimulation of tumor growth and metastasis. https://www.ncbi.nlm.nih.gov/pubmed/17347152