Recombinant Human Serpin A1 (C-6His)

Product Code:

ELK-EPT244

Product Group:

Recombinant Proteins

Host Type:

Human

Regulatory Status:

RUO

Shipping:

The product is shipped at ambient temperature.

Storage:

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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Code	Size	Price

ELK-EPT244-10ug

10ug

£308.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Accession:

AAH11991.1

Alternative Names:

Alpha-1-Antitrypsin; Alpha-1 Protease Inhibitor; Alpha-1-Antiproteinase; Serpin A1; SERPINA1; AAT; PI

Apparent Molecular Weight:

50-65 KDa, reducing conditions

Background:

Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.

Endotoxin:

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Molecular Weight:

45.35 KDa

Purity:

Greater than 95% as determined by reducing SDS-PAGE.

Redissolve:

Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?