TargetMol

CSRM617 hydrochloride

Product Code:
 
TAR-T10896L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T10896L-1mg1mg£177.00
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TAR-T10896L-1mL1 mL * 10 mM (in DMSO)£310.00
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TAR-T10896L-5mg5mg£334.00
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TAR-T10896L-10mg10mg£466.00
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TAR-T10896L-25mg25mg£704.00
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TAR-T10896L-50mg50mg£930.00
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Quantity:
TAR-T10896L-100mg100mg£1,219.00
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Quantity:
TAR-T10896L-500mg500mg£2,384.00
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This product comes from: United States.
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Further Information

Bioactivity:
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 ( OC2, a master regulator of androgen receptor) with a K d of 7.43 uM in SPR assays, directly binds to OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the mouse model of prostate cancer [1]
CAS:
1353749-74-2
Formula:
C10H14ClN3O5
Molecular Weight:
291.69
Pathway:
Apoptosis|Endocrinology/Hormones|Others
Purity:
0.9947
SMILES:
Cl.O=C(NN=CC1=CC=C(O)C(O)=C1O)C(N)CO
Target:
Others|Apoptosis|Androgen Receptor

References

Rotinen M, et, al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.