TargetMol

Oligomycin

Product Code:
 
TAR-T21494
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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Further Information

Bioactivity:
Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibited HIF-1alpha expression in hypoxic tumor cells.
CAS:
1404-19-9
Pathway:
Chromatin/Epigenetic|Angiogenesis
Purity:
0.98
SMILES:
CCC1CCC2OC3(CCC(C)C(CC(C)O)O3)C(C)C(OC(=O)C=CC(C)C(O)C(C)C(=O)C(C)C(O)C(C)C(=O)C(C)(O)C(O)C(C)CC=CC=C1)C2C |w:24.24,50.50,52.52|
Target:
HIF

References

Zhou W, et al. Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor. Biochim Biophys Acta Bioenerg. 2018;1859(9):789-796. L?pez de Figueroa P, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966-976. SMITH RM, PETERSON WH, McCOY E. Oligomycin, a new antifungal antibiotic. Antibiot Chemother (Northfield). 1954;4(9):962-970.