TargetMol

PF-4981517

Product Code:
 
TAR-T21548
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T21548-50mg50mgEnquire
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TAR-T21548-1mg1mg£103.00
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TAR-T21548-5mg5mg£148.00
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TAR-T21548-10mg10mg£195.00
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TAR-T21548-25mg25mg£321.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-4981517 is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 uM,17 uM, and 71 uM for CYP3A4, CYP3A5, and CYP3A7, respectively. PF-4981517 is able to be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug Metabolism.
CAS:
1390637-82-7
Molecular Weight:
456.59
Pathway:
Metabolism
Purity:
0.9977
SMILES:
CN1C=2C(C(=N1)C3=C(N(C)N=C3)C4=CC=C(C)C=C4)=C(N=CN2)N5C[C@H](CC5)N6CCCCC6
Target:
P450

References

Robert L Walsky, et al. Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. Drug Metab Dispos. 2012 Sep;40(9)