TargetMol

Tyrphostin A25

Product Code:
 
TAR-T21622
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T21622-1mg1mg£111.00
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TAR-T21622-5mg5mg£125.00
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TAR-T21622-10mg10mg£148.00
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TAR-T21622-25mg25mg£196.00
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TAR-T21622-50mg50mg£293.00
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TAR-T21622-100mg100mg£408.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tyrphostin A25 is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 uM for GPR35 and an EC50 value of 5.3 uM for GPR35.
CAS:
118409-58-8
Molecular Weight:
202.17
Pathway:
GPCR/G Protein|JAK/STAT signaling|Endocrinology/Hormones|Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
N#CC(C#N)=CC1=CC(O)=C(O)C(O)=C1
Target:
EGFR|GPR

References

Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989;32(10):2344-2352. Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994;127(3):859-866. Erlinge D, et al. Tyrphostin inhibition of ATP-stimulated DNA synthesis, cell proliferation and fos-protein expression in vascular smooth muscle cells. Br J Pharmacol. 1996;118(4):1028-1034. Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011;585(12):1957-1962.