TargetMol

Zearalenone-13C18

Product Code:
 
TAR-T35783
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T35783-1mg1mgEnquire
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Further Information

Bioactivity:
Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also induces degeneration of meiotic chromatin in oocytes and reduces fertility in pigs when administered at a dose of 200 ug/kg.4Zearalenone has been found as a contaminant in wheat, maize, and barley and livestock feeds.3,4
CAS:
911392-43-3
Molecular Weight:
336.231
Purity:
0.98
SMILES:
[13CH3][13C@H]1[13CH2][13CH2][13CH2][13C](=O)[13CH2][13CH2][13CH2]\[13CH]=[13CH]\[13c]2[13cH][13c](O)[13cH][13c](O)[13c]2[13C](=O)O1 |t:10|

References

Tiemann, U., and D?nicke, S.In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A reviewFood Addit. Contam.24(3)306-314(2007) Kuiper, G.G.J.M., Lemmen, J.G., Carlsson, B., et al.Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor ?Endocrinology139(10)4252-4263(1998) Richard, J.L.Some major mycotoxins and their mycotoxicoses?an overviewInt. J. Food Microbiol.119(1-2)3-10(2007) Zinedine, A., Soriano, J.M., Molt?, J.C., et al.Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxinFood Chem. Toxicol.45(1)1-18(2007)