TargetMol

20-carboxy Arachidonic Acid

Product Code:
 
TAR-T36232
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T36232-1mg1mgEnquire
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Further Information

Bioactivity:
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ? 0.12 uM) and PPARγ (Kd = 1.7 ? 0.5 uM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.
CAS:
79551-84-1
Formula:
C20H30O4
Molecular Weight:
334.456
Purity:
0.98
SMILES:
OC(=O)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O