TargetMol

BMS-599626 Hydrochloride

Product Code:
 
TAR-T5390
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T5390-1mg1mg£100.00
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TAR-T5390-5mg5mg£140.00
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TAR-T5390-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T5390-10mg10mg£177.00
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TAR-T5390-25mg25mg£274.00
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TAR-T5390-50mg50mg£430.00
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Quantity:
TAR-T5390-100mg100mg£600.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMS-599626 Hydrochloride is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 Hydrochloride inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.
CAS:
873837-23-1
Molecular Weight:
567.01
Pathway:
JAK/STAT signaling|Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
1
SMILES:
N(C=1C=2N(C=C(NC(OC[C@@H]3COCCN3)=O)C2C)N=CN1)C=4C=C5C(=CC4)N(CC6=CC(F)=CC=C6)N=C5.Cl
Target:
HER

References

Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61. Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.