TargetMol

USP5-IN-1

Product Code:
 
TAR-T60130
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60130-1mg1mg£177.00
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Quantity:
TAR-T60130-5mg5mg£330.00
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Quantity:
TAR-T60130-10mg10mg£455.00
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Quantity:
TAR-T60130-25mg25mg£703.00
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Quantity:
TAR-T60130-50mg50mg£938.00
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Quantity:
TAR-T60130-100mg100mg£1,259.00
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Quantity:
TAR-T60130-500mg500mg£2,456.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 uM and is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate [1].
Molecular Weight:
437.9
Pathway:
Cell Cycle/Checkpoint|Ubiquitination|DNA Damage/DNA Repair
Purity:
0.9953
SMILES:
O=C(O)CNC(=O)C1=CC=C(S(=O)(=O)N2CCC(C3=CC=C(Cl)C=C3)CC2)C=N1
Target:
DUB

References

Mann MK, et al. Structure-Activity Relationship of USP5 Inhibitors [published correction appears in J Med Chem. 2022 Jan 13;65(1):889]. J Med Chem. 2021;64(20):15017-15036.