TargetMol

PBRM1-BD2-IN-8

Product Code:
 
TAR-T60157
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60157-1mg1mg£209.00
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Quantity:
TAR-T60157-1mL1 mL * 10 mM (in DMSO)£412.00
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Quantity:
TAR-T60157-5mg5mg£418.00
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Quantity:
TAR-T60157-10mg10mg£575.00
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Quantity:
TAR-T60157-25mg25mg£854.00
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Quantity:
TAR-T60157-50mg50mg£1,107.00
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Quantity:
TAR-T60157-100mg100mg£1,492.00
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Quantity:
TAR-T60157-500mg500mg£2,922.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 uM, PBRM1-BD2 IC50=0.16 uM; PBRM1-BD5 Kd=25 uM). PBRM1-BD2-IN-8 shows anti-cancer activity.
CAS:
2819989-75-6
Molecular Weight:
317.18
Pathway:
Chromatin/Epigenetic
Purity:
0.9948
SMILES:
O=C1NC(NC=2C=CC=C(Br)C12)C=3C=CC=C(C3)C
Target:
Epigenetic Reader Domain

References

Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.