TargetMol

RP-6685

Product Code:
 
TAR-T60187
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60187-1mg1mg£230.00
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TAR-T60187-5mg5mg£483.00
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TAR-T60187-1mL1 mL * 10 mM (in DMSO)£522.00
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TAR-T60187-10mg10mg£670.00
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TAR-T60187-25mg25mg£1,002.00
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TAR-T60187-50mg50mg£1,324.00
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Quantity:
TAR-T60187-100mg100mg£1,741.00
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This product comes from: United States.
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Further Information

Bioactivity:
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Polθ), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Polθ. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
CAS:
2832047-80-8
Molecular Weight:
497.37
Pathway:
DNA Damage/DNA Repair|Cell Cycle/Checkpoint
Purity:
0.9834
SMILES:
O=C(N(C1=CC=C(F)C=C1)CC#CC2=NN=C(N)C=C2)CC3=NC=C(C=C3C(F)(F)F)C(F)(F)F
Target:
DNA/RNA Synthesis

References

Bubenik M, et al. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol?. J Med Chem. 2022 Sep 20.