TargetMol

DDO-7263

Product Code:
 
TAR-T60487
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60487-1mg1mg£137.00
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TAR-T60487-5mg5mg£229.00
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TAR-T60487-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T60487-10mg10mg£349.00
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TAR-T60487-25mg25mg£544.00
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TAR-T60487-50mg50mg£747.00
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Quantity:
TAR-T60487-100mg100mg£1,002.00
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This product comes from: United States.
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Further Information

Bioactivity:
DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1].
CAS:
2254004-96-9
Molecular Weight:
273.24
Pathway:
Immunology/Inflammation
Purity:
0.9975
SMILES:
FC=1C=CC(=CC1F)C2=NC(=NO2)C=3C=NC(=CC3)C
Target:
Nrf2

References

Dai Z, et al. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. J Med Chem. 2022 Mar 24;65(6):5029-5043. Xu LL, et al. 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress. Free Radic Biol Med. 2019 Apr;134:288-303.