TargetMol

NITD-916

Product Code:
 
TAR-T60774
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60774-1mg1mg£352.00
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TAR-T60774-5mg5mg£736.00
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TAR-T60774-10mg10mg£978.00
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TAR-T60774-25mg25mg£1,348.00
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Quantity:
TAR-T60774-50mg50mg£1,661.00
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This product comes from: United States.
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Further Information

Bioactivity:
NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits antituberculosis activity.
CAS:
1614262-83-7
Formula:
C20H25NO2
Molecular Weight:
311.42
Pathway:
Microbiology/Virology
Purity:
0.996
SMILES:
O=C1NC(=CC(O)=C1C=2C=CC=CC2)CC3CCC(C)(C)CC3
Target:
Antibiotic

References

McNeil MB, et al. Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA. Tuberculosis (Edinb). 2017 Dec;107:133-136. Manjunatha UH, et al. Direct inhibitors of InhA are active against Mycobacterium tuberculosis. Sci Transl Med. 2015 Jan 7;7(269):269ra3.