TargetMol

GSK-1482160

Product Code:
 
TAR-T61025
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61025-1mg1mg£98.00
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TAR-T61025-5mg5mg£135.00
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TAR-T61025-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T61025-10mg10mg£173.00
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TAR-T61025-25mg25mg£282.00
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TAR-T61025-50mg50mg£442.00
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Quantity:
TAR-T61025-100mg100mg£619.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.
CAS:
1001389-72-5
Molecular Weight:
334.72
Pathway:
Neuroscience|Membrane transporter/Ion channel
Purity:
0.9987
SMILES:
C(NC(=O)[C@H]1N(C)C(=O)CC1)C2=C(Cl)C(C(F)(F)F)=CC=C2
Target:
P2X Receptor

References

Ruan Z, et al. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 Aug 18;15(1):47. Ali Z, et al. Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects. Br J Clin Pharmacol. 2013 Jan;75(1):197-207.