TargetMol

EAI001

Product Code:
 
TAR-T61191
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61191-1mg1mg£95.00
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Quantity:
TAR-T61191-5mg5mg£114.00
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TAR-T61191-10mg10mg£144.00
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TAR-T61191-25mg25mg£217.00
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TAR-T61191-50mg50mg£311.00
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Quantity:
TAR-T61191-100mg100mg£458.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
CAS:
892772-75-7
Molecular Weight:
349.41
Pathway:
Tyrosine Kinase/Adaptors|Angiogenesis|JAK/STAT signaling
Purity:
0.98
SMILES:
O=C1C=2C=CC=CC2CN1C(C=3C=CC=CC3)C(=O)NC4=NC=CS4
Target:
EGFR

References

Maity S, et, al. Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance. Pharmacol Rep. 2020 Aug;72(4):799-813. Tinivella A, et, al. Investigating the selectivity of allosteric inhibitors for mutant t790m egfr over wild type using molecular dynamics and binding free energy calculations. 2018 Dec 4;3(12):16556-62.