TargetMol

VT103

Product Code:
 
TAR-T62077
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T62077-1mg1mg£227.00
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TAR-T62077-5mg5mg£460.00
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TAR-T62077-10mg10mg£627.00
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TAR-T62077-25mg25mg£962.00
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TAR-T62077-50mg50mg£1,267.00
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TAR-T62077-100mg100mg£1,653.00
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Quantity:
TAR-T62077-500mg500mg£3,243.00
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Further Information

Bioactivity:
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.
CAS:
2290608-13-6
Formula:
C18H17F3N4O2S
Molecular Weight:
410.41
Pathway:
Stem Cells
Purity:
0.9873
SMILES:
O=S(=O)(NC)C=1C=CC(NC2=CC=C(C=C2)C(F)(F)F)=C(C1)C=3N=CN(C3)C
Target:
YAP

References

Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998.