TargetMol

PKM2 activator 2

Product Code:
 
TAR-T62758
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T62758-1mg1mg£111.00
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Quantity:
TAR-T62758-5mg5mg£168.00
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Quantity:
TAR-T62758-10mg10mg£230.00
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TAR-T62758-25mg25mg£436.00
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Quantity:
TAR-T62758-50mg50mg£625.00
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Quantity:
TAR-T62758-100mg100mg£970.00
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Quantity:
TAR-T62758-500mg500mg£1,862.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through activation of PKM2.
CAS:
1186660-06-9
Molecular Weight:
452.49
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=S(=O)(C=1C=CC=2C=CC=CC2C1)N3CCN(CC3)S(=O)(=O)C=4C(F)=CC=CC4F
Target:
PKM

References

Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010;53(3):1048-1055.