TargetMol

CRK12-IN-1

Product Code:
 
TAR-T63059
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63059-1mg1mg£352.00
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Quantity:
TAR-T63059-5mg5mg£736.00
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Quantity:
TAR-T63059-10mg10mg£978.00
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Quantity:
TAR-T63059-25mg25mg£1,348.00
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Quantity:
TAR-T63059-50mg50mg£1,661.00
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Quantity:
TAR-T63059-100mg100mg£2,079.00
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Quantity:
TAR-T63059-500mg500mg£4,006.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CRK12-IN-1 is a potent CRK12 inhibitor.CRK12-IN-1 has insecticidal activity, with inhibitory effects on Trypanosoma brucei (T.b. brucei) and Trypanosoma congolense (T. congolense) with EC50s of 1.3 and 18 nM, respectively.CRK12-IN-1 kills the pathogenic cells rapidly.
CAS:
1990479-14-5
Molecular Weight:
472.57
Pathway:
Microbiology/Virology
Purity:
0.9929
SMILES:
C(=O)(C=1SC(N[C@@H]2CC[C@@H](NS(CC(C)C)(=O)=O)CC2)=NC1N)C3=C(F)C=CC=C3F
Target:
Antibiotic

References

Smith A, et al. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. J Med Chem. 2022;65(7):5606-5624.