TargetMol

ULK1-IN-2

Product Code:
 
TAR-T63343
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63343-1mg1mg£111.00
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Quantity:
TAR-T63343-5mg5mg£168.00
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TAR-T63343-10mg10mg£230.00
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TAR-T63343-25mg25mg£436.00
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Quantity:
TAR-T63343-50mg50mg£625.00
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Quantity:
TAR-T63343-100mg100mg£970.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 uM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer.
CAS:
2497409-01-3
Molecular Weight:
495.26
Pathway:
Autophagy|Apoptosis
Purity:
0.9976
SMILES:
O=N(=O)C1=CC=C(OC2=NC(=NC=C2Br)NC3=CC(OC)=C(OC)C(OC)=C3)C(F)=C1
Target:
Autophagy|Apoptosis

References

Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.