TargetMol

Cbl-b-IN-3

Product Code:
 
TAR-T63790
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63790-1mg1mg£378.00
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Quantity:
TAR-T63790-5mg5mg£805.00
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TAR-T63790-10mg10mg£1,075.00
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Quantity:
TAR-T63790-25mg25mg£1,556.00
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Quantity:
TAR-T63790-50mg50mg£2,062.00
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Quantity:
TAR-T63790-100mg100mg£2,777.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.
CAS:
2573775-59-2
Molecular Weight:
537.62
Pathway:
Ubiquitination
Purity:
0.9899
SMILES:
CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
Target:
E1/E2/E3 Enzyme

References

Arthur T., et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.