TargetMol

CSF1R-IN-3

Product Code:
 
TAR-T64066
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T64066-1mg1mg£182.00
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Quantity:
TAR-T64066-5mg5mg£349.00
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Quantity:
TAR-T64066-1mL1 mL * 10 mM (in DMSO)£423.00
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TAR-T64066-10mg10mg£523.00
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TAR-T64066-25mg25mg£785.00
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Quantity:
TAR-T64066-50mg50mg£1,058.00
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Quantity:
TAR-T64066-100mg100mg£1,412.00
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Quantity:
TAR-T64066-500mg500mg£2,761.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.
CAS:
2760584-90-3
Molecular Weight:
574.67
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9731
SMILES:
C(=C\1/C=2C(=CC(NC(NC=3C=C(C(C)(C)C)ON3)=O)=CC2)NC1=O)\C4=C(C)C(NC(CN5CCN(C)CC5)=O)=C(C)N4
Target:
CSF-1R|c-Fms

References

Lv Q, et al. Discovery of (Z)-1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021 ; 64(23):17184-17208.