TargetMol

AKI603

Product Code:
 
TAR-T64338
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T64338-1mg1mg£164.00
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TAR-T64338-5mg5mg£301.00
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TAR-T64338-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T64338-10mg10mg£454.00
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TAR-T64338-25mg25mg£704.00
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TAR-T64338-50mg50mg£938.00
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TAR-T64338-100mg100mg£1,259.00
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TAR-T64338-500mg500mg£2,456.00
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Further Information

Bioactivity:
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells[1][2].
CAS:
1432515-73-5
Molecular Weight:
409.45
Pathway:
Chromatin/Epigenetic|Cell Cycle/Checkpoint
Purity:
0.9981
SMILES:
Cc1cc(Nc2nc(Nc(cc3)ccc3[N+]([O-])=O)nc(N3CCN(C)CC3)c2)n[nH]1
Target:
Aurora Kinase

References

Le-Xun Wang, et al. Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation. Sci Rep. 2016 Nov 8;6:35533. Zhenzhen Zhao, et al. Determination of a novel Aurora-A (AurA) kinase AKI603 by UPLC-MS/MS and its application to a bioavailability study in rat. J Pharm Biomed Anal. 2016 Jun 5;125:303-9. Fei-Meng Zheng, et al. A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther. 2014 Aug;13(8):1991-2003.