TargetMol

QN523?

Product Code:
 
TAR-T64374
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T64374-1mg1mg£109.00
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TAR-T64374-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T64374-5mg5mg£161.00
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TAR-T64374-10mg10mg£213.00
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TAR-T64374-25mg25mg£362.00
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TAR-T64374-50mg50mg£530.00
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TAR-T64374-100mg100mg£731.00
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TAR-T64374-500mg500mg£1,428.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action.
CAS:
878581-60-3
Molecular Weight:
250.26
Pathway:
Autophagy
Purity:
0.9726
SMILES:
O=C(NC1=CC=CC2=CC=CN=C21)C3=NC=CN=C3
Target:
Autophagy

References

Kuang Y, et al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65(8):6133-6156.