TargetMol

Thiolutin

Product Code:
 
TAR-T67708
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67708-1mg1mg£168.00
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TAR-T67708-5mg5mg£309.00
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TAR-T67708-1mL1 mL * 10 mM (in DMSO)£340.00
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TAR-T67708-10mg10mg£462.00
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TAR-T67708-25mg25mg£840.00
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TAR-T67708-50mg50mg£1,139.00
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Quantity:
TAR-T67708-100mg100mg£1,508.00
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This product comes from: United States.
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Further Information

Bioactivity:
Thiolutin is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
CAS:
87-11-6
Molecular Weight:
228.29
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
O=C(NC=1C(=O)N(C2=CSSC12)C)C
Target:
Antibiotic|Antibacterial

References

Jia Y, et al. Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. Cell Stress Chaperones. 2010 Mar;15(2):165-81. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.