TargetMol

C004019

Product Code:
 
TAR-T67834
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67834-1mg1mg£335.00
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TAR-T67834-5mg5mg£711.00
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TAR-T67834-10mg10mg£946.00
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TAR-T67834-25mg25mg£1,396.00
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TAR-T67834-50mg50mg£1,862.00
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TAR-T67834-100mg100mg£2,424.00
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Further Information

Bioactivity:
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
CAS:
2417159-57-8
Molecular Weight:
1035.29
Pathway:
PROTAC|Cytoskeletal Signaling
Purity:
0.9937
SMILES:
N(CC(NCCOCCOCCOCC(N[C@H](C(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1)C(C)(C)C)=O)=O)(C)C4=NC(=NC(NCCC5=CC=CS5)=N4)N6CCN(C(C)=O)CCC6
Target:
PROTACs|Microtubule Associated

References

Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021;11(11):5279-5295.