TargetMol

Butyzamide

Product Code:
 
TAR-T67894
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67894-1mg1mg£299.00
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Quantity:
TAR-T67894-5mg5mg£622.00
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TAR-T67894-10mg10mg£872.00
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TAR-T67894-25mg25mg£1,259.00
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TAR-T67894-50mg50mg£1,669.00
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Quantity:
TAR-T67894-100mg100mg£2,231.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
CAS:
1110767-45-7
Molecular Weight:
591.55
Pathway:
Immunology/Inflammation|Stem Cells|Angiogenesis|Chromatin/Epigenetic|JAK/STAT signaling
Purity:
0.9871
SMILES:
CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
Target:
JAK|Thrombopoietin Receptor

References

Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008;93(10):1495-1504.