TargetMol

Litoxetine

Product Code:
 
TAR-T67956
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67956-1mg1mg£149.00
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TAR-T67956-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T67956-5mg5mg£254.00
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TAR-T67956-10mg10mg£346.00
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TAR-T67956-25mg25mg£541.00
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TAR-T67956-50mg50mg£744.00
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TAR-T67956-100mg100mg£1,002.00
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TAR-T67956-500mg500mg£1,934.00
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Further Information

Bioactivity:
Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).
CAS:
86811-09-8
Molecular Weight:
241.33
Pathway:
Neuroscience|GPCR/G Protein
Purity:
0.9912
SMILES:
O(CC=1C=CC=2C=CC=CC2C1)C3CCNCC3
Target:
5-HT Receptor

References

Lucchelli A, et al. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundam Clin Pharmacol. 1999 ; 13(3):330-336. Fairweather DB, et al. The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers. Br J Clin Pharmacol. 1995 ; 40(2):119-125. Lucchelli A, et al. The interaction of antidepressant drugs with central and peripheral (enteric) 5-HT3 and 5-HT4 receptors. Br J Pharmacol. 1995 ; 114(5):1017-1025. Dmochowski RR, et al. A randomized, placebo-controlled clinical development program exploring the use of litoxetine for treating urinary incontinence. Neurourol Urodyn. 2021 ; 40(6):1515-1523.