TargetMol

Fezolamine

Product Code:
 
TAR-T68070
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68070-1mg1mg£160.00
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TAR-T68070-5mg5mg£279.00
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TAR-T68070-10mg10mg£384.00
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TAR-T68070-25mg25mg£595.00
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TAR-T68070-50mg50mg£816.00
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TAR-T68070-100mg100mg£1,083.00
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Quantity:
TAR-T68070-500mg500mg£2,103.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals.
CAS:
80410-36-2
Molecular Weight:
305.42
Pathway:
Neuroscience
Purity:
0.9985
SMILES:
N1=C(C=2C=CC=CC2)C(=CN1CCCN(C)C)C=3C=CC=CC3
Target:
Norepinephrine

References

Baizman ER, et al. Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models. J Pharmacol Exp Ther. 1987;243(1):40-54. McCoy L, et al. Determination of fezolamine and its desmethyl metabolite in human plasma and urine by high-performance liquid chromatography. Intravenous pharmacokinetics in the beagle hound. J Chromatogr. 1985;344:211-220. Zisook S, et al. Efficacy and safety of fezolamine in depressed patients. Neuropsychobiology. 1987;17(3):133-138.