TargetMol

Mofarotene

Product Code:
 
TAR-T68104
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68104-1mg1mg£158.00
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TAR-T68104-5mg5mg£287.00
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TAR-T68104-10mg10mg£392.00
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TAR-T68104-25mg25mg£607.00
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TAR-T68104-50mg50mg£833.00
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TAR-T68104-100mg100mg£1,107.00
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Quantity:
TAR-T68104-500mg500mg£2,143.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Mofarotene is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and respiratory diseases.Mofarotene is a retinoic acid analog that binds to and activates retinoic acid receptors (RARs), which alters the expression of certain genes, leading to reduced cell differentiation and cell proliferation in susceptible cells.
CAS:
125533-88-2
Molecular Weight:
433.63
Pathway:
Metabolism
Purity:
0.9936
SMILES:
CC1(C)C=2C(C(C)(C)CC1)=CC=C(\C(=C\C3=CC=C(OCCN4CCOCC4)C=C3)\C)C2
Target:
Retinoid Receptor

References

Valles B, et al. Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995;23(10):1051-1057. Eliason JF, et al. Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells. Blood. 1995;86(12):4516-4526. Vall?s B, et al. In vivo and in vitro kinetics of mofarotene in mouse, rat, dog and man. Eur J Drug Metab Pharmacokinet. 1995;20(1):49-53.