TargetMol

Saterinone

Product Code:
 
TAR-T68138
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T68138-1mg1mg£197.00
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TAR-T68138-5mg5mg£384.00
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TAR-T68138-1mL1 mL * 10 mM (in DMSO)£439.00
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TAR-T68138-10mg10mg£544.00
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TAR-T68138-25mg25mg£828.00
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TAR-T68138-50mg50mg£1,099.00
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TAR-T68138-100mg100mg£1,460.00
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TAR-T68138-500mg500mg£2,850.00
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Further Information

Bioactivity:
Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory properties and can be used in the acute treatment of chronic heart failure. Saterinone inhibited crude cAMP phosphodiesterase (PDE) activity in guinea pig right ventricular homogenates The ic50 value is 2.3 x 10(-5) mol/l.
CAS:
102669-89-6
Molecular Weight:
441.35
Pathway:
GPCR/G Protein|Neuroscience|Metabolism
Purity:
1
SMILES:
C([C@H](NC(=O)C1=CC(Cl)=CC(Cl)=C1)CCC(O)=O)(=O)N2CCC3(CC2)CCCC3
Target:
PDE|Adrenergic Receptor

References

Brunkhorst D, et al. Selective inhibition of cAMP phosphodiesterase III activity by the cardiotonic agent saterinone in guinea pig myocardium. Arzneimittelforschung. 1988;38(9):1293-1298. Iven H, et al. Electrophysiologic effects of saterinone and milrinone in the isolated guinea pig myocardium. Arzneimittelforschung. 1988;38(9):1298-1302. Kieback AG, et al. Saterinone, dobutamine, and sodium nitroprusside: comparison of cardiovascular profiles in patients with congestive heart failure. J Cardiovasc Pharmacol. 1998;32(4):629-636.