TargetMol

3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile

Product Code:
 
TAR-T72022
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T72022-1mg1mg£352.00
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TAR-T72022-5mg5mg£736.00
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TAR-T72022-10mg10mg£978.00
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TAR-T72022-25mg25mg£1,348.00
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TAR-T72022-50mg50mg£1,661.00
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Quantity:
TAR-T72022-100mg100mg£2,079.00
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Quantity:
TAR-T72022-500mg500mg£4,006.00
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Further Information

Bioactivity:
3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
CAS:
946400-19-7
Molecular Weight:
461.86
Purity:
0.9946
SMILES:
C(F)(F)(F)C1=C(N2C[C@@H](C)N(S(=O)(=O)C3=C(Cl)C=C(C#N)C=C3)CC2)C=CC(F)=C1

References

Wan ZK, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem. 2009 Sep 10;52(17):5449-61.