TargetMol

PCSK9-IN-10

Product Code:
 
TAR-T72025
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T72025-1mg1mg£103.00
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TAR-T72025-5mg5mg£148.00
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TAR-T72025-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T72025-10mg10mg£195.00
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TAR-T72025-25mg25mg£322.00
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Quantity:
TAR-T72025-50mg50mg£466.00
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Quantity:
TAR-T72025-100mg100mg£653.00
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Quantity:
TAR-T72025-500mg500mg£1,291.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PCSK9-IN-10 is a potent and orally active PCSK9 inhibitor with an IC 50 value of 6.4 uM. PCSK9-IN-10 increases the expression of LDLR protein and decreases the expression of PCSK9. PCSK9-IN-10 reduces atherosclerosis progression. PCSK9-IN-10 has the potential for the research of hyperlipidemia .
CAS:
368434-98-4
Molecular Weight:
373.41
Pathway:
Cell Cycle/Checkpoint|Metabolism
Purity:
0.9885
SMILES:
O=C1C2=C(N=C(NCCOC)N2CC=3C=CC=C(OC)C3)N(C(=O)N1C)C
Target:
Serine/threonin kinase

References

Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2023;247:115047.