TargetMol

R 59-022 hydrochloride

Product Code:
 
TAR-T72322
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T72322-1mg1mg£101.00
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TAR-T72322-5mg5mg£142.00
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TAR-T72322-10mg10mg£189.00
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TAR-T72322-25mg25mg£309.00
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TAR-T72322-50mg50mg£454.00
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TAR-T72322-100mg100mg£623.00
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TAR-T72322-500mg500mg£1,211.00
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Further Information

Bioactivity:
R 59-022 hydrochloride is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 uM) that inhibits the phosphorylation of OAG to OAPA.R 59-022 enhances thrombin-induced triglyceride production in platelets and inhibits the production of phosphatidic acid in neutrophils. R 59-022 enhances thrombin-induced diglyceride production in platelets and inhibits phosphatidic acid production in neutrophils.
CAS:
93076-98-3
Molecular Weight:
496.04
Pathway:
GPCR/G Protein|Neuroscience|Cytoskeletal Signaling|Chromatin/Epigenetic
Purity:
0.977
SMILES:
Cl.O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3
Target:
PKC|5-HT Receptor

References

Dominguez CL, et al. Diacylglycerol kinase ? is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. Cancer Discov. 2013;3(7):782-797. de Chaffoy de Courcelles DC, et al. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J Biol Chem. 1985;260(29):15762-15770. Stewart CM, et al. A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells. Viruses. 2019;11(3):206. Nunn DL, et al. A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J. 1987;243(3):809-813. Boroda S, et al. Dual activities of ritanserin and R59022 as DGK? inhibitors and serotonin receptor antagonists. Biochem Pharmacol. 2017;123:29-39. Jones JA, et al. Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenaline release and phosphoinositide hydrolysis in chromaffin cells. Br J Pharmacol. 1990;101(3):521-526.