TargetMol

Miclxin

Product Code:
 
TAR-T73415
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T73415-1mg1mg£148.00
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TAR-T73415-5mg5mg£262.00
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TAR-T73415-10mg10mg£389.00
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TAR-T73415-25mg25mg£624.00
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TAR-T73415-50mg50mg£857.00
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TAR-T73415-100mg100mg£1,131.00
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Quantity:
TAR-T73415-500mg500mg£2,199.00
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This product comes from: United States.
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Further Information

Bioactivity:
Miclxin is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent inhibitor of mutant β-catenin, which is involved in the Wnt signaling pathway.Miclxin induces β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin has anti-tumor activity and kills tumors by targeting MIC60.
CAS:
2494198-61-5
Formula:
C26H27N5O2
Molecular Weight:
441.52
Pathway:
Stem Cells|Cytoskeletal Signaling
Purity:
0.9957
SMILES:
N=1C=CC=C(C1)C2CN(C=3N=C4C=C(OC)C=CC4=C(N3)NCC=5C=CC=C(OC)C5)CC2
Target:
Wnt/beta-catenin

References

Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in ?-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020;15(8):2195-2204.