TargetMol

PROTAC-O4I2

Product Code:
 
TAR-T74186
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T74186-1mg1mg£114.00
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TAR-T74186-5mg5mg£173.00
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TAR-T74186-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T74186-10mg10mg£230.00
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TAR-T74186-25mg25mg£436.00
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TAR-T74186-50mg50mg£703.00
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TAR-T74186-100mg100mg£1,099.00
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TAR-T74186-500mg500mg£2,143.00
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Further Information

Bioactivity:
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 uM. PROTAC-O4I2 induced apoptosis in K562 WT cells.
CAS:
2785323-62-6
Molecular Weight:
609.1
Pathway:
Apoptosis|PROTAC
Purity:
0.98
SMILES:
O=C(NCCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C=4N=C(SC4)NC5=CC=C(Cl)C=C5
Target:
PROTACs|Apoptosis

References

Rodrigo A Gama-Brambila, et al. A PROTAC targets splicing factor 3BCell Chem Biol. 2021 Nov 18;28(11):1616-1627.e8.