TargetMol

Nurr1 agonist 2

Product Code:
 
TAR-T77549
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T77549-1mg1mg£227.00
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TAR-T77549-5mg5mg£416.00
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TAR-T77549-10mg10mg£581.00
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TAR-T77549-25mg25mg£863.00
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TAR-T77549-50mg50mg£1,163.00
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TAR-T77549-100mg100mg£1,540.00
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Quantity:
TAR-T77549-500mg500mg£3,026.00
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Further Information

Bioactivity:
Nurr1 agonist 2 is a Nurr1 agonist with an EC50 value of 0.07 uM. Nurr1 agonist 2 increases the mRNA expression of the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand-binding domain (LBD) with a Kd of 0.14 uM. Nurr1 agonist 2 can be used to study parkinsonism.
CAS:
742058-34-0
Molecular Weight:
310.37
Purity:
0.98
SMILES:
O=C(O)C=1SC(=CC1)C=2C=CC(OCC=3C=CC=CC3)=CC2

References

Ballarotto M, et al. De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem. 2023 Jun 22;66(12):8170-8177.