TargetMol

AG-10

Product Code:
 
TAR-T9447
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T9447-1mg1mg£227.00
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Quantity:
TAR-T9447-1mL1 mL * 10 mM (in DMSO)£407.00
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Quantity:
TAR-T9447-5mg5mg£430.00
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Quantity:
TAR-T9447-10mg10mg£600.00
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Quantity:
TAR-T9447-25mg25mg£863.00
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Quantity:
TAR-T9447-50mg50mg£1,179.00
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Quantity:
TAR-T9447-100mg100mg£1,589.00
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Quantity:
TAR-T9447-500mg500mg£3,115.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AG-10 is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis.
CAS:
1446711-81-4
Molecular Weight:
292.31
Purity:
0.9977
SMILES:
O=C(O)C1=CC=C(F)C(OCCCC=2C(=NNC2C)C)=C1

References

Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8. Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129.