TargetMol

Valinomycin

Product Code:
 
TAR-TP1072
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TP1072-2mg2mg£94.00
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Quantity:
TAR-TP1072-1mL1 mL * 10 mM (in DMSO)£230.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
CAS:
2001-95-8
Molecular Weight:
1111.32
Pathway:
Microbiology/Virology|Apoptosis|PI3K/Akt/mTOR signaling|Autophagy
Purity:
1
SMILES:
[C@@H](C)(C)[C@@H]1C(=O)N[C@H]([C@H](C)C)C(=O)O[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]([C@@H](C)C)C(=O)N[C@H]([C@@H](C)C)C(=O)O[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@H]([C@@H](C)C)C(=O)N[C@H]([C@@H](C)C)C(=O)O[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O1
Target:
Autophagy|PTEN|Apoptosis|Antibiotic|Antibacterial

References

Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080. Abdalah R1, Wei L, Francis K, Yu SP. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Epub 2006 Jul 20. Chen X C, Tang G X, Luo W H, et al. Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. Journal of the American Chemical Society. 2021 Krote? MA, Bartoszewicz M, Swiecicka I. Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities. Pol J Microbiol. 2010;59(1):3-10.