TargetMol

HMG499

Product Code:
 
TAR-T11572
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T11572-5mg5mg£1,167.00
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Quantity:
TAR-T11572-50mg50mg£2,307.00
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Quantity:
TAR-T11572-100mg100mg£2,898.00
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This product comes from: United States.
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Further Information

Bioactivity:
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 uM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1].
CAS:
2416941-68-7
Formula:
C33H54O3
Molecular Weight:
498.78
Pathway:
Metabolism
Purity:
0.98
SMILES:
O[C@H](C1(C)C)CC[C@@]2(C)C1=C[C@H](O)C3C2CC[C@@]4(C)C3CC[C@@H]4[C@@H](CCCC(CC=C)(O)CC=C)C
Target:
HMG-CoA Reductase

References

Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9(1):5138.