TargetMol

Lifirafenib

Product Code:
 
TAR-T22272
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: United States.
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Further Information

Bioactivity:
Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
CAS:
1446090-79-4
Molecular Weight:
478.42
Pathway:
MAPK|JAK/STAT signaling|Angiogenesis|Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
O=C1Nc2nccc(Oc(cc3)cc(C45)c3OC4C5c3nc(ccc(C(F)(F)F)c4)c4[nH]3)c2CC1
Target:
EGFR|Raf

References

Tang Z, et al. Mol Cancer Ther. 2015, 14(10):2187-97.