TargetMol

JTT 130

Product Code:
 
TAR-T24223
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T24223-5mg5mg£1,171.00
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Quantity:
TAR-T24223-50mg50mg£2,303.00
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Quantity:
TAR-T24223-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein.
CAS:
916683-32-4
Molecular Weight:
718.71
Purity:
0.98
SMILES:
CCOC(=O)C(COC(=O)CC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)C(=O)N(C)C)(C4=CC=CC=C4)C(=O)OCC

References

Sakata S, Ito M, Mera Y, Sasase T, Yamamoto H, Kakutani M, Ohta T. JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats. J Diabetes Res. 2014;2014:803832. doi: 10.1155/2014/803832. Epub 2014 May 7. PubMed PMID: 24895641; PubMed Central PMCID: PMC4033514. Mera Y, Kawai T, Ogawa N, Odani N, Sasase T, Miyajima K, Ohta T, Kakutani M. JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models. J Pharmacol Sci. 2015 Nov;129(3):169-76. doi: 10.1016/j.jphs.2015.10.004. Epub 2015 Oct 20. PubMed PMID: 26598005. Sakata S, Katsumi S, Mera Y, Kuroki Y, Nashida R, Kakutani M, Ohta T. Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats. J Pharmacol Sci. 2015 Jan;127(1):103-8. doi: 10.1016/j.jphs.2014.11.004. Epub 2014 Nov 22. PubMed PMID: 25704025. Mera Y, Hata T, Ishii Y, Tomimoto D, Kawai T, Ohta T, Kakutani M. JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, reduces food preference for fat. J Diabetes Res. 2014;2014:583752. doi: 10.1155/2014/583752. Epub 2014 May 15. PubMed PMID: 24959597; PubMed Central PMCID: PMC4052484.