TargetMol

TD52 dihydrochloride

Product Code:
 
TAR-T35528L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
❮❯

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CodeSizePrice
TAR-T35528L-5mg5mg£125.00
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Quantity:
TAR-T35528L-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T35528L-10mg10mg£173.00
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TAR-T35528L-25mg25mg£302.00
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Quantity:
TAR-T35528L-50mg50mg£434.00
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Quantity:
TAR-T35528L-100mg100mg£605.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
TD52 dihydrochloride, a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti-cancer activity while displaying less inhibition of p-EGFR.
Molecular Weight:
433.33
Purity:
0.9846
SMILES:
C#CC1=CC=CC(NC2=NC3=C(N=C2NC4=CC(C#C)=CC=C4)C=CC=C3)=C1.Cl.Cl

References

Chun-Yu Liu, et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.