TargetMol

Thalidomide-Cyanine 5

Product Code:
 
TAR-T41174
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T41174-5mg5mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Thalidomide-Cyanine 5 is a fluorescent probe for cereblon E3 ligases. Binds with high affinity to DDB1-CRBN. Suitable for use in TR-FRET.
Purity:
0.98

References

Chessum et al (2018) Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766). J.Med.Chem. 61 918 PMID: 29240418 Petzold et al (2016) Structural basis of lenalidomide-induced CK1? degradation by the CRL4 CRBN ubiquitin ligase. Nature 532 127 PMID: 26909574 Cavadini et al (2016) Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome. Nature 531 598 PMID: 27029275 Fischer et al (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512 49 PMID: 25043012