TargetMol

PA Nic

Product Code:
 
TAR-T41210
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T41210-5mg5mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ? 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.
Purity:
0.98

References

Yan et al (2018) Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission. Cell Rep. 23 2236 PMID: 29791835 Arvin et al (2019) Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine. J.Vis.Exp. 143 e58873 PMID: 30735191 Banala et al (2018) Photoactivatable drugs for nicotinic optopharmacology. Nat.Methods 15 347 PMID: 29578537