TargetMol

MMRi62

Product Code:
 
TAR-T60202
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60202-5mg5mg£124.00
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TAR-T60202-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T60202-10mg10mg£165.00
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TAR-T60202-25mg25mg£269.00
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TAR-T60202-50mg50mg£385.00
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TAR-T60202-100mg100mg£546.00
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Quantity:
TAR-T60202-500mg500mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.
CAS:
352693-80-2
Molecular Weight:
396.27
Pathway:
Apoptosis
Purity:
0.997
SMILES:
ClC1=CC=CC(=C1Cl)C(NC2=NC=CC=C2)C=3C=CC4=CC=CN=C4C3O
Target:
Ferroptosis

References

Li J, et al. Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53. Mol Cancer Ther. 2022 Apr 1;21(4):535-545. Lama R, et al. Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status. Front Oncol. 2022 Aug 5;12:933446.