TargetMol

NLRP3/AIM2-IN-2

Product Code:
 
TAR-T60404
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T60404-5mg5mg£108.00
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Quantity:
TAR-T60404-1mL1 mL * 10 mM (in DMSO)£112.00
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Quantity:
TAR-T60404-10mg10mg£135.00
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Quantity:
TAR-T60404-25mg25mg£201.00
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Quantity:
TAR-T60404-50mg50mg£269.00
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Quantity:
TAR-T60404-100mg100mg£369.00
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Quantity:
TAR-T60404-500mg500mg£768.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ? 0.0233 u M.
CAS:
791840-86-3
Formula:
C15H15NO3
Molecular Weight:
257.28
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
O=C(NC=1C=CC=C(O)C1)CC2=CC=C(OC)C=C2
Target:
AIM2

References

Jiao Y,et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022;232:114194. Zhang R, et al. New Highly Potent NLRP3 Inhibitors: Furanochalcone Velutone F Analogues. ACS Med Chem Lett. 2022;13(4):560-569.