TargetMol

FNDR-20123 free base

Product Code:
 
TAR-T61572
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T61572-5mg5mg£850.00
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Quantity:
TAR-T61572-50mg50mg£1,661.00
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Quantity:
TAR-T61572-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
FNDR-20123 free base is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC 50 s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 free base exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC 50 =41 nM) and sexual blood stage (IC 50 =190 nM for male gametocytes). FNDR-20123 free base inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC 50 =25, 29, 2, 11, and 282 nM, respectively) and inhibits Class III HDAC isoforms at nanomolar concentrations [1].
CAS:
1267502-34-0
Formula:
C21H23N5O2
Molecular Weight:
377.448
Purity:
0.98
SMILES:
ONC(=O)c1ccc(Cn2cc(nn2)-c2ccc(CN3CCCC3)cc2)cc1