TargetMol

AKR1C3-IN-9

Product Code:
 
TAR-T67846
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T67846-5mg5mg£122.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T67846-1mL1 mL * 10 mM (in DMSO)£127.00
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Quantity:
TAR-T67846-10mg10mg£148.00
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Quantity:
TAR-T67846-25mg25mg£229.00
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Quantity:
TAR-T67846-50mg50mg£334.00
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Quantity:
TAR-T67846-100mg100mg£503.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AKR1C3-IN-9 is a selective Aldo-keto Reductase 1C3 (AKR1C3) inhibitor (IC50= 8.92 nM). AKR1C3-IN-9 can significantly reverse the Doxorubicin (DOX) resistance in a resistant breast cancer cell line.
Molecular Weight:
352.38
Pathway:
Metabolism
Purity:
0.9941
SMILES:
CC1=C(C(=NO1)C)COC2=CC=CC=C2C(=O)NC3=CC=CC=C3OC
Target:
NADPH

References

Liu Y, et al. Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur J Med Chem. 2022 Dec 13;247:115013.